Endocrine Abstracts

Anti-obesity therapeutics based on increasing the amount of brown fat have received more attention from industry as the biology and regulation of brown fat are better understood than that of beige fat. Cold exposure and treatment with β3 adrenergic receptor agonist are known to activate brown/beige adipose tissue. Many transcriptional pathways regulating brown/beige adipose tissue have been identified, the role of lipid biosynthetic enzymes in brown/beige adipose tissue h...

Recent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of metabolic diseases. Treatment of CL-316243, a β3-adrenergic receptor agonist, activates brown/beige adipocytes and can cause significant reductions in adiposity. Many transcriptional pathways regulating brown/beige adipose tissue have been identified, the role of lipid biosynthetic enzymes in brown/beige adipose tissu...